Activation of meiosis

Across TCGA patient cohorts, RNA activity of the Activation of meiosis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRPX2, MSX2_S91, and DOCK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of meiosis activity versus SRPX2 in BRCA (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SRPX2 →	+0.653	+0.077	.005	<.001	3	6
BRCA	MSX2_S91 →	+1.106	+0.092	<.001	<.001	3	6
UCEC	DOCK1 →	+0.284	+0.112	<.001	.001	3	6
UCEC	TNFAIP8 →	-0.363	-0.106	.005	.002	3	6
BRCA	SBF2 →	+0.242	+0.069	.001	.002	3	5
BRCA	STXBP1 →	+0.328	+0.057	.009	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090427 vs SRPX2 — BRCA

Explore this scatter interactively →