Activation of meiosis

Across TCGA patient cohorts, RNA activity of the Activation of meiosis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM63A, HPN-AS1, and MYC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of meiosis activity versus TMEM63A in CCRCC (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TMEM63A →	+0.976	+0.623	<.001	.002	3	4
GBM	HPN-AS1 →	+0.443	+0.624	<.001	<.001	3	4
BRCA	MYC →	-0.858	-0.217	.007	.007	3	4
CCRCC	HERC2P9 →	+0.379	+0.499	.004	.004	3	4
HNSC	CD274 →	-1.151	-0.142	.001	.006	3	4
COAD	PBK →	-1.591	-0.201	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090427 vs TMEM63A — CCRCC

Explore this scatter interactively →