Activation of meiosis

Across TCGA cell cohorts, RNA activity of the Activation of meiosis pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCOA2, SLC7A5, and MRPS21, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NCOA2 grouped by Activation of meiosis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NCOA2 →	-0.166	-1.173	.002	<.001	3	4
BLOOD_Leukemia	SLC7A5 →	+0.169	+0.855	.004	.003	2	5
BLOOD_Leukemia	MRPS21 →	+0.260	+1.217	.001	<.001	3	4
BREAST	TOX →	+0.175	+0.610	<.001	.008	3	4
LARGE_INTESTINE	MKNK1 →	-0.076	-0.700	.003	.009	3	4
LUNG_NSCLC_LUAD	MED15 →	+0.190	+0.844	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NCOA2 by Activation of meiosis activity — OVARY

Explore this box plot interactively →