Acinar cell differentiation

pathway activity — cross-omics
GO:0090425Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Acinar cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BST1, NCF4, and CP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMBST1 →-0.822-0.118<.001<.00137
LSCCNCF4 →-0.484-0.061.003.00237
GBMCP →-0.557-0.081<.001<.00137
GBMFCN1 →-1.168-0.097.002<.00137
GBMTBC1D2B →-0.349-0.078.001.00236
OVC1R →-0.655-0.074.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration