Oncogene-induced cell senescence

Across TCGA patient cohorts, RNA activity of the Oncogene-induced cell senescence pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SKAP2, THEMIS2_T593, and TYMP, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oncogene-induced cell senescence activity versus SKAP2 in OV (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SKAP2 →	+0.586	+0.079	<.001	<.001	3	10
HNSC	THEMIS2_T593 →	+0.687	+0.092	<.001	<.001	3	10
OV	TYMP →	+0.718	+0.090	<.001	<.001	3	10
UCEC	BTK →	+0.556	+0.117	<.001	<.001	3	10
BRCA	FCER1G →	+0.797	+0.077	<.001	<.001	3	10
HNSC	GBP1 →	+0.855	+0.066	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090402 vs SKAP2 — OV

Explore this scatter interactively →