Oncogene-induced cell senescence

Across TCGA patient cohorts, RNA activity of the Oncogene-induced cell senescence pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGA2, DSE, and PLAU, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oncogene-induced cell senescence activity versus HMGA2 in GBM (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HMGA2 →	+1.268	+0.234	<.001	<.001	3	5
GBM	DSE →	+0.482	+0.256	.007	.003	3	5
LUAD	PLAU →	+1.074	+0.278	<.001	<.001	3	5
GBM	PPP1R18 →	+0.453	+0.250	<.001	<.001	3	5
LUAD	IGF2BP2-AS1 →	+0.708	+0.219	.001	.003	3	5
GBM	SPHK1 →	+0.710	+0.187	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090402 vs HMGA2 — GBM

Explore this scatter interactively →