Oncogene-induced cell senescence

Across TCGA cell cohorts, RNA activity of the Oncogene-induced cell senescence pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCU, MGAT4B, and CMTM8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MCU grouped by Oncogene-induced cell senescence-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MCU →	-0.812	-0.870	.001	.004	3	5
BREAST	MGAT4B →	-0.727	-1.041	<.001	<.001	3	5
OVARY	CMTM8 →	-1.129	-1.035	.002	.005	3	5
BREAST	RND3 →	-1.749	-1.326	<.001	<.001	3	4
BREAST	WDR36 →	-0.610	-1.204	.001	<.001	3	4
SOFT_TISSUE	ANXA1 →	-3.659	-1.120	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MCU by Oncogene-induced cell senescence activity — BREAST

Explore this box plot interactively →