Oncogene-induced cell senescence

Across TCGA cell cohorts, RNA activity of the Oncogene-induced cell senescence pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PML, RTP4, and C11orf68, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oncogene-induced cell senescence activity versus PML in LUNG_NSCLC_LUAD (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PML →	+1.505	+0.901	<.001	.002	3	8
BLOOD_Lymphoma	RTP4 →	+1.517	+0.232	.009	.007	3	6
LARGE_INTESTINE	C11orf68 →	+1.177	+0.545	<.001	.005	3	6
LUNG_NSCLC_LUAD	FOSL1 →	+2.451	+0.544	<.001	.005	3	6
PANCREAS	RPS7 →	-0.967	-0.403	.001	.005	3	5
LARGE_INTESTINE	IFI44 →	+2.122	+0.442	.005	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090402 vs PML — LUNG_NSCLC_LUAD

Explore this scatter interactively →