Stress-induced premature senescence

Across TCGA patient cohorts, RNA activity of the Stress-induced premature senescence pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF3J_S127, MAP1B, and PEAK1_Y635, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stress-induced premature senescence activity versus EIF3J_S127 in HNSC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EIF3J_S127 →	-0.472	-0.046	<.001	.003	3	5
CCRCC	MAP1B →	+0.648	+0.089	<.001	<.001	3	5
BRCA	PEAK1_Y635 →	+0.680	+0.052	.004	<.001	3	5
PDAC	SMARCA2_S1528 →	+0.333	+0.051	<.001	<.001	3	5
PDAC	AKAP12_S651 →	+0.518	+0.042	.005	.005	3	5
CCRCC	MAP1B_S2271 →	+0.809	+0.080	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090400 vs EIF3J_S127 — HNSC

Explore this scatter interactively →