Stress-induced premature senescence

Across TCGA patient cohorts, RNA activity of the Stress-induced premature senescence pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02664, MIR6812, and CUBN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stress-induced premature senescence activity versus LINC02664 in LUAD (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC02664 →	-0.182	-0.134	.007	.008	3	4
GBM	MIR6812 →	+0.465	+0.182	.006	.004	3	4
GBM	CUBN →	-0.452	-0.234	.007	.002	2	4
OV	RPL39L →	+0.833	+0.486	.001	.001	3	3
OV	NUP37 →	+0.366	+0.389	.003	.004	3	3
CCRCC	KLHL7-DT →	+0.434	+0.387	<.001	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090400 vs LINC02664 — LUAD

Explore this scatter interactively →