Stress-induced premature senescence

Across TCGA cell cohorts, RNA activity of the Stress-induced premature senescence pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP53, CDKN1A, and MDM2, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TP53 grouped by Stress-induced premature senescence-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TP53 →	-0.871	-1.745	<.001	<.001	3	15
SKIN	CDKN1A →	-0.520	-1.771	<.001	<.001	3	12
SKIN	MDM2 →	+0.711	+1.398	<.001	<.001	3	11
KIDNEY	USP28 →	-0.362	-1.783	.001	<.001	3	10
KIDNEY	ADRM1 →	+0.318	+1.394	<.001	.001	3	10
STOMACH	USP7 →	+0.660	+1.477	.002	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TP53 by Stress-induced premature senescence activity — SKIN

Explore this box plot interactively →