Stress-induced premature senescence

Across TCGA cell cohorts, RNA activity of the Stress-induced premature senescence pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMS1, PYCR1, and BLNK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBMS1 grouped by Stress-induced premature senescence-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RBMS1 →	+0.407	+0.199	.001	.001	3	5
BONE	PYCR1 →	+0.169	+0.184	.008	.006	3	5
BLOOD_Leukemia	BLNK →	+0.314	+0.193	.001	<.001	3	5
LUNG_SCLC	ASB6 →	+0.264	+0.221	<.001	.001	3	5
BREAST	MYO5A →	+0.116	+0.094	.001	.005	3	4
BLOOD_Leukemia	PRDM12 →	-0.190	-0.116	.008	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBMS1 by Stress-induced premature senescence activity — BONE

Explore this box plot interactively →