Stress-induced premature senescence

Across TCGA cell cohorts, RNA activity of the Stress-induced premature senescence pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALHM2, CDC42BPG, and AMBP, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stress-induced premature senescence activity versus CALHM2 in LUNG_NSCLC_LUAD (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CALHM2 →	+2.235	+0.890	<.001	.002	3	3
SKIN	CDC42BPG →	+0.760	+0.394	.008	.006	3	3
BLOOD_Leukemia	AMBP →	-0.221	-1.163	.001	.001	3	3
BLOOD_Leukemia	CD68 →	+3.026	+1.002	<.001	<.001	3	3
BLOOD_Leukemia	HAX1 →	-0.534	-0.764	.007	.004	3	3
BLOOD_Leukemia	CALR →	+0.824	+0.784	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090400 vs CALHM2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →