Replicative senescence

Across TCGA patient cohorts, RNA activity of the Replicative senescence pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HOOK1, PLOD2, and MME, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Replicative senescence activity versus HOOK1 in UCEC (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HOOK1 →	-0.362	-0.094	<.001	<.001	3	7
OV	PLOD2 →	+0.788	+0.063	.004	.001	3	7
PDAC	MME →	+0.942	+0.060	<.001	<.001	3	7
LUAD	THBS2 →	+0.717	+0.058	.003	.003	3	6
PDAC	ITGA5 →	+0.719	+0.063	<.001	<.001	3	6
BRCA	IKBIP →	+0.552	+0.048	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090399 vs HOOK1 — UCEC

Explore this scatter interactively →