Replicative senescence

Across TCGA patient cohorts, RNA activity of the Replicative senescence pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATAD5, GTSE1, and EIF3B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Replicative senescence activity versus ATAD5 in LUAD (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ATAD5 →	+0.604	+0.810	<.001	<.001	3	5
LUAD	GTSE1 →	+0.934	+1.052	<.001	<.001	3	5
BRCA	EIF3B →	+0.341	+0.767	<.001	<.001	3	5
BRCA	MCM5 →	+0.541	+0.658	.004	.007	3	4
LUAD	NUDT1 →	+0.538	+0.932	<.001	<.001	3	4
LUAD	HROB →	+0.841	+0.943	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090399 vs ATAD5 — LUAD

Explore this scatter interactively →