Replicative senescence

Across TCGA cell cohorts, RNA activity of the Replicative senescence pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDB2, EDA2R, and ZMAT3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDB2 grouped by Replicative senescence-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DDB2 →	-1.709	-1.723	<.001	<.001	3	7
SKIN	EDA2R →	-2.142	-1.779	<.001	<.001	3	7
SKIN	ZMAT3 →	-1.407	-1.769	<.001	<.001	3	6
SKIN	CDKN1A →	-2.512	-1.512	<.001	<.001	3	5
SKIN	MDM2 →	-1.492	-1.795	<.001	<.001	3	5
SKIN	FDXR →	-0.989	-1.272	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDB2 by Replicative senescence activity — SKIN

Explore this box plot interactively →