Replicative senescence

Across TCGA cell cohorts, RNA activity of the Replicative senescence pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF14, RHOV, and SPRYD4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Replicative senescence activity versus RNF14 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RNF14 →	-1.253	-1.898	.006	<.001	3	4
LUNG_NSCLC_LUSC	RHOV →	-1.210	-1.691	.003	<.001	3	4
OVARY	SPRYD4 →	-0.356	-1.833	.008	<.001	3	4
URINARY_TRACT	AXDND1 →	+0.255	+1.788	.009	.006	3	4
PANCREAS	SLC12A7 →	-1.138	-1.609	.002	.002	3	3
PANCREAS	RALGPS1 →	-1.334	-1.483	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090399 vs RNF14 — UPPER_AERODIGESTIVE_TRACT

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