Negative regulation of excitatory postsynaptic potential

Across TCGA patient cohorts, RNA activity of the Negative regulation of excitatory postsynaptic potential pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRRM2_S456, BCCIP, and CD8A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of excitatory postsynaptic potential activity versus SRRM2_S456 in BRCA (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SRRM2_S456 →	-0.837	-0.035	.002	.004	3	6
LSCC	BCCIP →	-0.429	-0.051	.001	.007	3	6
CCRCC	CD8A →	+0.664	+0.073	<.001	.001	3	5
LSCC	DLC1_S1254 →	+0.792	+0.069	<.001	<.001	3	5
HNSC	EIF3F_S258 →	-0.604	-0.073	.002	<.001	3	5
LUAD	SET →	-0.206	-0.064	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090394 vs SRRM2_S456 — BRCA

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