Negative regulation of excitatory postsynaptic potential

Across TCGA patient cohorts, RNA activity of the Negative regulation of excitatory postsynaptic potential pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRK2, PTGIR, and LINC01215, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of excitatory postsynaptic potential activity versus LRRK2 in LSCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LRRK2 →	+1.347	+1.235	<.001	<.001	3	5
LSCC	PTGIR →	+0.549	+1.004	.001	<.001	3	5
COAD	LINC01215 →	+0.391	+0.360	<.001	.004	3	5
HNSC	RASAL3 →	+0.585	+0.555	.006	.001	3	5
LUAD	FAM20A →	+0.511	+0.609	<.001	.003	3	5
LUAD	TYROBP →	+0.461	+0.953	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090394 vs LRRK2 — LSCC

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