Negative regulation of excitatory postsynaptic potential

Across TCGA patient cohorts, RNA activity of the Negative regulation of excitatory postsynaptic potential pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNE1_S378, SYNE1_S8223, and SYNE1_T538, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of excitatory postsynaptic potential activity versus SYNE1_S378 in LUAD (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SYNE1_S378 →	+0.879	+1.193	<.001	<.001	3	5
LUAD	SYNE1_S8223 →	+0.879	+1.193	<.001	<.001	3	5
LSCC	SYNE1_T538 →	+0.599	+1.164	<.001	<.001	2	6
LSCC	SYNE1_T8360 →	+0.599	+1.164	<.001	<.001	2	6
UCEC	CYRIA →	+0.434	+0.841	<.001	<.001	3	5
LUAD	SYNE1 →	+0.395	+1.131	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090394 vs SYNE1_S378 — LUAD

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