Phagosome-lysosome fusion

Across TCGA patient cohorts, RNA activity of the Phagosome-lysosome fusion pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLEKHA4_S575, C1orf116_S560, and ELAC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phagosome-lysosome fusion activity versus PLEKHA4_S575 in COAD (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLEKHA4_S575 →	+0.629	+0.040	.004	.003	2	5
LUAD	C1orf116_S560 →	+1.071	+0.070	.002	<.001	3	4
LSCC	ELAC2 →	-0.245	-0.036	.001	.002	3	4
LUAD	FOLR1 →	+0.663	+0.056	.001	.002	3	4
LSCC	HSPB1 →	+0.597	+0.048	<.001	<.001	3	4
COAD	LRRC59 →	-0.267	-0.034	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090385 vs PLEKHA4_S575 — COAD

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