Phagosome-lysosome fusion

Across TCGA patient cohorts, RNA activity of the Phagosome-lysosome fusion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAWR, LAT, and TRAJ7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phagosome-lysosome fusion activity versus PAWR in BRCA (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PAWR →	-0.626	-0.575	.001	<.001	3	3
CCRCC	LAT →	-0.102	-0.512	.005	.002	3	3
LUAD	TRAJ7 →	+0.674	+0.630	.006	.008	2	4
GBM	SLC9A2 →	-0.169	-0.146	.004	.001	3	3
GBM	RALGPS2 →	-0.602	-0.168	.001	<.001	3	3
GBM	MIR3162 →	-0.565	-0.166	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090385 vs PAWR — BRCA

Explore this scatter interactively →