Phagosome-lysosome fusion

Across TCGA cell cohorts, RNA activity of the Phagosome-lysosome fusion pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB7B, RAB39A, and RAB20, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB7B grouped by Phagosome-lysosome fusion-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RAB7B →	-0.413	-1.404	.005	.001	2	9
OVARY	RAB39A →	-0.221	-1.232	<.001	.001	3	7
KIDNEY	RAB20 →	-0.228	-1.118	<.001	.001	3	6
STOMACH	EIPR1 →	+0.140	+0.958	.003	<.001	3	4
LARGE_INTESTINE	RAB34 →	-0.153	-1.184	.002	.004	2	5
LUNG_NSCLC_LUAD	LBX1 →	+0.141	+0.762	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB7B by Phagosome-lysosome fusion activity — SOFT_TISSUE

Explore this box plot interactively →