Phagosome-lysosome fusion

Across TCGA cell cohorts, RNA activity of the Phagosome-lysosome fusion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPAST, UBXN2A, and DNAI4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPAST grouped by Phagosome-lysosome fusion-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPAST →	+0.505	+0.604	.002	.004	2	5
SOFT_TISSUE	UBXN2A →	+0.741	+1.436	.004	<.001	3	4
STOMACH	DNAI4 →	+0.763	+1.053	.002	.007	3	4
CNS	PAFAH1B3 →	+0.767	+1.166	<.001	<.001	3	3
SKIN	CHTF18 →	+0.378	+0.686	.006	.009	3	3
SKIN	TMPRSS9 →	-0.305	-1.070	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPAST by Phagosome-lysosome fusion activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →