Phagosome-lysosome fusion

Across TCGA cell cohorts, RNA activity of the Phagosome-lysosome fusion pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS33B, RECQL5, and DNAL4, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phagosome-lysosome fusion activity versus VPS33B in OESOPHAGUS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	VPS33B →	+0.851	+0.137	.001	.004	3	14
PANCREAS	RECQL5 →	+0.840	+0.080	<.001	<.001	3	8
PANCREAS	DNAL4 →	+0.504	+0.047	.007	.008	3	7
BLOOD_Leukemia	TMEM175 →	+0.734	+0.089	<.001	<.001	2	8
UPPER_AERODIGESTIVE_TRACT	COG3 →	+0.899	+0.083	<.001	.006	3	7
URINARY_TRACT	RAB20 →	+1.536	+0.092	.009	.004	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090385 vs VPS33B — OESOPHAGUS

Explore this scatter interactively →