Phagosome-lysosome fusion

Across TCGA cell cohorts, RNA activity of the Phagosome-lysosome fusion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNCG, DEGS1, and LAMP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phagosome-lysosome fusion activity versus SNCG in LUNG_SCLC (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SNCG →	-1.887	-0.181	.002	.001	3	5
STOMACH	DEGS1 →	+1.742	+0.260	.001	<.001	3	5
BLOOD_Leukemia	LAMP1 →	+0.718	+0.203	.005	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ACAD9 →	+0.645	+0.117	.005	.006	3	4
BREAST	UFSP1 →	+0.682	+0.140	<.001	.008	3	4
BONE	ADAMTS9 →	+1.027	+0.269	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090385 vs SNCG — LUNG_SCLC

Explore this scatter interactively →