Phagosome maturation

Across TCGA patient cohorts, RNA activity of the Phagosome maturation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DEF6, GMIP, and ICAM1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phagosome maturation activity versus DEF6 in CCRCC (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DEF6 →	+0.472	+0.055	<.001	<.001	3	9
GBM	GMIP →	+0.359	+0.052	<.001	.002	3	9
GBM	ICAM1 →	+0.567	+0.067	.001	<.001	3	9
GBM	LCP1 →	+0.810	+0.083	<.001	<.001	3	9
GBM	PLCB2 →	+0.396	+0.058	<.001	<.001	3	9
LSCC	RIN3 →	+0.307	+0.062	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090382 vs DEF6 — CCRCC

Explore this scatter interactively →