Phagosome maturation

Across TCGA patient cohorts, RNA activity of the Phagosome maturation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD86, DOK3, and ITGB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phagosome maturation activity versus CD86 in CCRCC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CD86 →	+0.509	+0.427	.004	.001	3	5
OV	DOK3 →	+0.801	+0.156	.005	.006	3	5
COAD	ITGB2 →	+0.759	+0.220	.002	.001	3	5
CCRCC	LILRB4 →	+0.605	+0.333	.007	.002	3	5
CCRCC	PILRA →	+0.533	+0.418	<.001	<.001	3	5
COAD	IFFO1 →	+0.402	+0.234	.009	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090382 vs CD86 — CCRCC

Explore this scatter interactively →