Phagosome maturation

Across TCGA cell cohorts, RNA activity of the Phagosome maturation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC6A9, ITGB1, and LIF, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phagosome maturation activity versus SLC6A9 in BONE (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SLC6A9 →	-2.485	-0.370	.005	.001	3	6
BONE	ITGB1 →	+1.503	+0.314	.007	.001	3	6
BONE	LIF →	+3.243	+0.314	.001	.001	3	5
BONE	CTSL →	+2.658	+0.314	.002	.001	3	5
BLOOD_Lymphoma	PIK3CD →	+2.337	+0.197	<.001	<.001	3	5
SOFT_TISSUE	PARD6G →	-1.403	-0.245	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090382 vs SLC6A9 — BONE

Explore this scatter interactively →