Negative regulation of cholesterol efflux

Across TCGA patient cohorts, RNA activity of the Negative regulation of cholesterol efflux pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R18_S224, ABCC3_S911, and EPB41L5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cholesterol efflux activity versus PPP1R18_S224 in CCRCC (Pearson r = 0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PPP1R18_S224 →	-0.302	-0.047	<.001	<.001	3	4
PDAC	ABCC3_S911 →	+0.639	+0.056	<.001	<.001	3	4
PDAC	EPB41L5 →	+0.231	+0.061	.001	<.001	3	4
PDAC	ANK3_S959 →	+0.400	+0.049	.004	.001	3	4
UCEC	BCAS1_S552 →	+0.929	+0.074	.004	.009	3	4
UCEC	MLPH_S574 →	+0.698	+0.089	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090370 vs PPP1R18_S224 — CCRCC

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