Negative regulation of cholesterol efflux

Across TCGA cell cohorts, RNA activity of the Negative regulation of cholesterol efflux pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDRG2, PPP2R2C, and KMT5C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDRG2 grouped by Negative regulation of cholesterol efflux-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NDRG2 →	+2.653	+1.523	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PPP2R2C →	-1.461	-1.025	.003	.009	3	4
UPPER_AERODIGESTIVE_TRACT	KMT5C →	+1.549	+1.280	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CCDC24 →	+1.156	+1.271	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CTAGE15 →	+0.853	+1.250	<.001	.006	3	4
LUNG_NSCLC_LUSC	SLC1A5 →	+1.365	+1.414	.004	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDRG2 by Negative regulation of cholesterol efflux activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →