Negative regulation of cholesterol efflux

Across TCGA cell cohorts, RNA activity of the Negative regulation of cholesterol efflux pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFA2, IAPP, and MEP1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDUFA2 grouped by Negative regulation of cholesterol efflux-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NDUFA2 →	+0.094	+0.214	.008	<.001	3	5
LUNG_NSCLC_LUSC	IAPP →	+0.178	+0.192	.005	.005	3	4
BONE	MEP1B →	+0.192	+0.217	.007	.009	3	4
KIDNEY	KCNMB1 →	+0.177	+0.228	.003	.002	3	3
KIDNEY	GPR6 →	+0.321	+0.231	<.001	.001	3	3
LUNG_SCLC	UFM1 →	-0.201	-0.189	.003	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDUFA2 by Negative regulation of cholesterol efflux activity — OVARY

Explore this box plot interactively →