Regulation of brown fat cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of brown fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3H11A, BTAF1, and ZBED6, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of brown fat cell differentiation activity versus ZC3H11A in DLBC (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	ZC3H11A →	+1.058	+0.037	<.001	.001	3	27
DLBC	BTAF1 →	+1.967	+0.053	<.001	<.001	3	27
CHOL	ZBED6 →	+2.184	+0.086	<.001	<.001	3	26
CHOL	MON2 →	+0.936	+0.078	.001	.001	3	26
DLBC	POGZ →	+0.993	+0.046	<.001	.003	3	25
DLBC	EIF4A1 →	+0.948	+0.041	<.001	.005	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090335 vs ZC3H11A — DLBC

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