Regulation of brown fat cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of brown fat cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CFL1, CXorf38, and RANBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of brown fat cell differentiation activity versus CFL1 in HNSC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CFL1 →	-0.193	-0.057	.006	.004	3	5
UCEC	CXorf38 →	-0.344	-0.090	.002	<.001	3	5
BRCA	RANBP1 →	-0.312	-0.038	<.001	<.001	3	5
UCEC	PLA2G4A_S437 →	+1.127	+0.067	<.001	<.001	3	5
UCEC	EIF3G →	-0.102	-0.042	.005	.008	3	5
GBM	WDR6 →	-0.105	-0.049	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090335 vs CFL1 — HNSC

Explore this scatter interactively →