Regulation of brown fat cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of brown fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLIPR2, SLC39A12, and RN7SL629P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of brown fat cell differentiation activity versus GLIPR2 in LSCC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GLIPR2 →	-0.348	-0.262	.003	.005	3	3
LSCC	SLC39A12 →	-0.109	-0.352	.006	.002	3	3
LSCC	RN7SL629P →	-0.378	-0.319	.008	.002	3	3
LUAD	MIR3165 →	+0.549	+0.193	.003	.004	3	3
HNSC	SHISAL1 →	-0.581	-0.545	.002	<.001	3	3
HNSC	ZFYVE28 →	-0.565	-0.633	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090335 vs GLIPR2 — LSCC

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