Regulation of locomotion involved in locomotory behavior

Across TCGA patient cohorts, RNA activity of the Regulation of locomotion involved in locomotory behavior pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIPOR2, ZNF385A, and CDC6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of locomotion involved in locomotory behavior activity versus RIPOR2 in HNSC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RIPOR2 →	+0.710	+0.625	<.001	.005	2	5
CCRCC	ZNF385A →	-0.619	-0.743	<.001	<.001	3	4
LSCC	CDC6 →	-0.895	-0.991	<.001	<.001	3	4
LSCC	DNAJC2 →	-0.403	-0.667	.001	.003	3	4
PDAC	GPR107 →	-0.260	-0.827	.002	<.001	3	4
LSCC	DHX35 →	-0.517	-0.917	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090325 vs RIPOR2 — HNSC

Explore this scatter interactively →