Regulation of locomotion involved in locomotory behavior

Across TCGA cell cohorts, RNA activity of the Regulation of locomotion involved in locomotory behavior pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNT9A, ELOF1, and C5orf34, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WNT9A grouped by Regulation of locomotion involved in locomotory behavior-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	WNT9A →	+1.000	+0.177	.008	.001	3	3
CNS	ELOF1 →	-1.894	-2.383	.001	.004	3	3
CNS	C5orf34 →	-1.434	-2.383	.002	.004	3	3
STOMACH	CD70 →	-2.948	-0.311	.004	<.001	3	3
LUNG_NSCLC_LUSC	CCDC92 →	-1.902	-0.513	<.001	.001	3	3
LUNG_NSCLC_LUSC	DYNC1I2 →	-0.562	-0.386	.006	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WNT9A by Regulation of locomotion involved in locomotory behavior activity — BLOOD_Myeloma

Explore this box plot interactively →