Regulation of superoxide metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of superoxide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIN3, HCLS1, and ANKRD44, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of superoxide metabolic process activity versus RIN3 in OV (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RIN3 →	+0.588	+0.064	<.001	<.001	3	9
GBM	HCLS1 →	+0.746	+0.098	<.001	<.001	3	9
OV	ANKRD44 →	+0.536	+0.072	<.001	<.001	3	9
GBM	WAS →	+0.602	+0.094	<.001	<.001	3	8
OV	CLIC2 →	+0.533	+0.062	<.001	<.001	3	8
LSCC	FGD3 →	+0.467	+0.088	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090322 vs RIN3 — OV

Explore this scatter interactively →