Regulation of superoxide metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of superoxide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTP1, MAP1B, and POGK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of superoxide metabolic process activity versus GSTP1 in BREAST (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GSTP1 →	+3.129	+0.213	.004	<.001	3	7
BREAST	MAP1B →	+2.635	+0.288	<.001	<.001	3	6
OESOPHAGUS	POGK →	-0.635	-0.281	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PHKA1 →	-0.975	-0.256	.002	.001	3	5
KIDNEY	POGLUT2 →	+1.840	+0.225	.006	.003	3	5
BREAST	FMNL3 →	+1.249	+0.304	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090322 vs GSTP1 — BREAST

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