Positive regulation of intracellular protein transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of intracellular protein transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, SEPTIN4_S432, and TIMP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of intracellular protein transport activity versus RPL5 in LSCC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPL5 →	-0.164	-0.038	<.001	<.001	3	6
HNSC	SEPTIN4_S432 →	+0.575	+0.052	.002	.005	3	6
BRCA	TIMP2 →	+0.490	+0.022	.001	<.001	3	6
CCRCC	C1QA →	+0.516	+0.028	.007	.002	3	6
COAD	C1QB →	+0.473	+0.020	.001	.007	3	6
CCRCC	C1QC →	+0.559	+0.030	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090316 vs RPL5 — LSCC

Explore this scatter interactively →