Positive regulation of intracellular protein transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of intracellular protein transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KTN1, OPTN, and RALGPS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KTN1 grouped by Positive regulation of intracellular protein transport-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	KTN1 →	-1.104	-0.283	.003	.002	3	5
STOMACH	OPTN →	-1.550	-0.232	.004	<.001	3	5
LUNG_SCLC	RALGPS1 →	+1.488	+0.182	.001	.001	3	4
BONE	SCOC →	-0.908	-0.264	<.001	.008	3	4
BONE	IL4R →	-2.316	-0.265	.002	.003	3	4
BLOOD_Leukemia	NRGN →	-2.313	-0.152	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KTN1 by Positive regulation of intracellular protein transport activity — BONE

Explore this box plot interactively →