Positive regulation of protein targeting to membrane

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein targeting to membrane pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CES1, AHNAK_S1452, and EBNA1BP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein targeting to membrane activity versus CES1 in OV (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CES1 →	+0.620	+0.031	.001	<.001	3	5
BRCA	AHNAK_S1452 →	+0.606	+0.031	.004	<.001	3	5
GBM	EBNA1BP2 →	-0.458	-0.077	<.001	<.001	3	5
GBM	GPKOW →	-0.159	-0.046	<.001	<.001	3	5
COAD	MFAP2 →	+0.484	+0.026	<.001	<.001	3	5
GBM	MTREX →	-0.207	-0.048	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090314 vs CES1 — OV

Explore this scatter interactively →