Regulation of protein targeting to membrane

Across TCGA patient cohorts, RNA activity of the Regulation of protein targeting to membrane pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERBB2, ORMDL2, and NEDD8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein targeting to membrane activity versus ERBB2 in HNSC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ERBB2 →	+0.592	+0.278	.006	.006	3	4
LUAD	ORMDL2 →	+0.253	+0.167	.002	.009	3	3
LUAD	NEDD8 →	+0.277	+0.191	.003	<.001	3	3
LUAD	SLC12A9 →	+0.327	+0.167	.005	.007	3	3
LUAD	GRHL3 →	+0.583	+0.162	.002	.006	3	3
LUAD	ENTR1 →	+0.302	+0.187	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090313 vs ERBB2 — HNSC

Explore this scatter interactively →