Regulation of protein targeting to membrane

Across TCGA cell cohorts, RNA activity of the Regulation of protein targeting to membrane pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIN3B, NR2C2, and SIRPA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SIN3B grouped by Regulation of protein targeting to membrane-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SIN3B →	-1.501	-0.928	.001	.009	3	4
BREAST	NR2C2 →	-0.534	-0.581	.005	.009	3	4
SKIN	SIRPA →	-1.283	-0.691	.005	.006	3	4
SOFT_TISSUE	GMPPB →	-0.768	-0.711	.002	.001	3	4
BONE	ICE1 →	-0.773	-1.074	<.001	.003	3	3
BLOOD_Leukemia	CAPN3 →	-2.254	-0.880	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SIN3B by Regulation of protein targeting to membrane activity — SOFT_TISSUE

Explore this box plot interactively →