Regulation of protein targeting to membrane

Across TCGA cell cohorts, RNA activity of the Regulation of protein targeting to membrane pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STOM, DPH5, and E2F2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein targeting to membrane activity versus STOM in BREAST (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	STOM →	+2.125	+1.305	<.001	.001	3	7
OESOPHAGUS	DPH5 →	-0.603	-0.965	.005	.006	3	6
BLOOD_Leukemia	E2F2 →	-1.785	-1.008	<.001	<.001	3	6
LIVER	CHD4 →	-0.940	-1.986	<.001	<.001	3	6
BLOOD_Leukemia	GOT2 →	-0.537	-0.960	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	STRBP →	-1.102	-1.234	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090313 vs STOM — BREAST

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