Positive regulation of protein deacetylation

pathway activity — cross-omics
GO:0090312Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein deacetylation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAGLN, FCER1A, and MYH11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCTAGLN →-0.976-0.324.001.00525
LSCCFCER1A →-0.718-0.242.004.00934
PDACMYH11 →-0.751-0.176.002.00134
BRCAARRDC4 →-0.686-0.380<.001.00134
BRCASPARCL1 →-0.921-0.497<.001<.00134
BRCADLC1 →-0.470-0.378.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration