Regulation of protein deacetylation

Across TCGA patient cohorts, RNA activity of the Regulation of protein deacetylation pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNISR, CCNT2, and LUC7L3, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein deacetylation activity versus PNISR in UVM (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	PNISR →	+1.859	+0.055	<.001	<.001	3	32
UVM	CCNT2 →	+1.628	+0.058	<.001	<.001	3	32
UVM	LUC7L3 →	+1.939	+0.056	<.001	<.001	3	31
UVM	FNBP4 →	+1.589	+0.056	<.001	<.001	3	31
UVM	NKTR →	+1.563	+0.058	<.001	<.001	3	31
UVM	INO80D →	+1.158	+0.056	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090311 vs PNISR — UVM

Explore this scatter interactively →