Regulation of protein deacetylation

Across TCGA patient cohorts, RNA activity of the Regulation of protein deacetylation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS2, SEPTIN4, and DDAH2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein deacetylation activity versus RPS2 in CCRCC (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPS2 →	-0.261	-0.065	<.001	<.001	3	8
GBM	SEPTIN4 →	+0.500	+0.049	<.001	<.001	3	8
LSCC	DDAH2 →	+0.453	+0.051	<.001	<.001	3	8
GBM	FRY →	+0.382	+0.078	<.001	<.001	3	8
BRCA	KANK2 →	+0.397	+0.037	<.001	<.001	3	8
CCRCC	DTX3 →	+0.475	+0.058	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090311 vs RPS2 — CCRCC

Explore this scatter interactively →