Regulation of protein deacetylation

Across TCGA cell cohorts, RNA activity of the Regulation of protein deacetylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THEMIS2, PLEKHA1, and MAGED1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, THEMIS2 grouped by Regulation of protein deacetylation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	THEMIS2 →	-0.781	-0.307	.001	.001	3	5
LUNG_SCLC	PLEKHA1 →	+0.909	+0.350	.006	<.001	3	4
LUNG_SCLC	MAGED1 →	+0.883	+0.355	.006	<.001	3	4
SOFT_TISSUE	HIF1A →	-1.489	-0.404	.001	.001	3	4
SOFT_TISSUE	RASSF4 →	-3.416	-0.377	.001	.002	3	4
SOFT_TISSUE	DPYSL3 →	-5.605	-0.453	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

THEMIS2 by Regulation of protein deacetylation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →