Regulation of protein deacetylation

Across TCGA cell cohorts, RNA activity of the Regulation of protein deacetylation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF407, CDS2, and SWSAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein deacetylation activity versus ZNF407 in SOFT_TISSUE (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZNF407 →	+0.554	+0.338	.009	.002	3	4
LUNG_SCLC	CDS2 →	+0.437	+0.338	.004	<.001	3	4
LIVER	SWSAP1 →	-0.590	-0.289	.001	.004	3	4
KIDNEY	CPLANE1 →	+1.058	+0.240	.005	.006	3	4
STOMACH	EID2B →	+1.465	+0.349	.003	.001	2	5
BLOOD_Myeloma	NRL →	-0.657	-0.395	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090311 vs ZNF407 — SOFT_TISSUE

Explore this scatter interactively →